The Russian movie “Sadko” and bylinas about Sadko (2)

Havelange Isabelle, Huguet Françoise, Lebedeff-Choppin Bernadette. NISARD Jean Marie Napoléon Désiré. In: , . Les inspecteurs généraux de l'Instruction publique. Dictionnaire biographique 1802-1914. Paris : Institut national de recherche pédagogique, 1986. pp. 524-525. (Histoire biographique de l'enseignement, 11

Mary's Song

sermon text; MS Word documen

An article on teaching Chinese characters to Japanese learners from the cognitive perspective

Havelange Isabelle, Huguet Françoise, Lebedeff-Choppin Bernadette. LA BLANCHÈRE Marie René MOULLIN du COUDRAY de. In: , . Les inspecteurs généraux de l'Instruction publique. Dictionnaire biographique 1802-1914. Paris : Institut national de recherche pédagogique, 1986. pp. 431-432. (Histoire biographique de l'enseignement, 11

Differences in regulation of the first two M-phases in Xenopus laevis embryo cell-free extracts

AbstractThe first embryonic M-phase is special, being the time when paternal and maternal chromosomes mix together for the first time. Reports from a variety of species suggest that the regulation of first M-phase has many particularities; however, no systematic comparative study of the biochemical aspects of first and the following M-phases has been previously undertaken. Here, we ask whether the regulation of the first embryonic M-phase is modified, using Xenopus cell-free extracts. We developed new types of extract specific for the first and the second M-phase obtained either from parthenogenetic or from in vitro fertilized embryos. Analyses of these extracts confirmed that the amplitude of histone H1 kinase activity reflecting CDK1/cyclin B (or MPF for M-phase Promoting Factor) activity is higher and persists longer than during the second M-phase, and that levels of cyclins B1 and B2 are correspondingly higher during the first than the second embryonic M-phase. Inhibition of protein synthesis shortly before M-phase entry reduced mitotic histone H1 kinase amplitude, shortened the period of mitotic phosphorylation of chosen marker proteins, and reduced cyclin B1 and B2 levels, suggesting a role of B-type cyclins in regulating the duration of mitotic events. Moreover, addition of exogenous cyclin B to the extract prior the second mitosis brought forward the activation of mitotic histone H1 kinase but prolonged the duration of this activity. We also confirmed that the inhibitory phosphorylation of CDK1 on tyrosine 15 oscillates between the first two embryonic M-phases, but is clearly more pronounced before the first than the second mitosis, while the MAP kinase ERK2 tended to show greater activation during the first embryonic M-phase but with a similar duration of activation. We conclude that discrete differences exist between the first two M-phases in Xenopus embryo and that higher CDK1/cyclin B activity and B-type cyclin levels could account for the different characteristics of these M-phases

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments.

International audienceSHANK genes code for scaffold proteins located at the post-synaptic density of glutamatergic synapses. In neurons, SHANK2 and SHANK3 have a positive effect on the induction and maturation of dendritic spines, whereas SHANK1 induces the enlargement of spine heads. Mutations in SHANK genes have been associated with autism spectrum disorders (ASD), but their prevalence and clinical relevance remain to be determined. Here, we performed a new screen and a meta-analysis of SHANK copy-number and coding-sequence variants in ASD. Copy-number variants were analyzed in 5,657 patients and 19,163 controls, coding-sequence variants were ascertained in 760 to 2,147 patients and 492 to 1,090 controls (depending on the gene), and, individuals carrying de novo or truncating SHANK mutations underwent an extensive clinical investigation. Copy-number variants and truncating mutations in SHANK genes were present in ∼1% of patients with ASD: mutations in SHANK1 were rare (0.04%) and present in males with normal IQ and autism; mutations in SHANK2 were present in 0.17% of patients with ASD and mild intellectual disability; mutations in SHANK3 were present in 0.69% of patients with ASD and up to 2.12% of the cases with moderate to profound intellectual disability. In summary, mutations of the SHANK genes were detected in the whole spectrum of autism with a gradient of severity in cognitive impairment. Given the rare frequency of SHANK1 and SHANK2 deleterious mutations, the clinical relevance of these genes remains to be ascertained. In contrast, the frequency and the penetrance of SHANK3 mutations in individuals with ASD and intellectual disability-more than 1 in 50-warrant its consideration for mutation screening in clinical practice

256 - Maturini Corderii Colloquia scholastica, commodiori nunc ordine quinque libris composita et quibusdam aliis ad commodiorem juventutis institutionem pertinentibus, opera Ramberti Horaei exornata

Huguet Françoise. 256 - Maturini Corderii Colloquia scholastica, commodiori nunc ordine quinque libris composita et quibusdam aliis ad commodiorem juventutis institutionem pertinentibus, opera Ramberti Horaei exornata. In: , . Les Livres pour l'Enfance et la Jeunesse de Gutenberg à Guizot. Les collections de la Bibliothèque de l'Institut National de Recherche Pédagogique. Paris : Institut national de recherche pédagogique, 1997. p. 108. (Bibliothèque de l'Histoire de l'Education, 16

748 - Cabinet (Le) du jeune naturaliste ou tableaux intéressants de l'histoire des animaux ; offrant la description de la nature, des mœurs et des habitudes des quadrupèdes, oiseaux, poissons, amphibies, reptiles, etc. Les plus remarquables du monde connu, et classés dans un ordre systématique : ouvrage enrichi de soixante-cinq belles gravures

Huguet Françoise. 748 - Cabinet (Le) du jeune naturaliste ou tableaux intéressants de l'histoire des animaux ; offrant la description de la nature, des mœurs et des habitudes des quadrupèdes, oiseaux, poissons, amphibies, reptiles, etc. Les plus remarquables du monde connu, et classés dans un ordre systématique : ouvrage enrichi de soixante-cinq belles gravures. In: , . Les Livres pour l'Enfance et la Jeunesse de Gutenberg à Guizot. Les collections de la Bibliothèque de l'Institut National de Recherche Pédagogique. Paris : Institut national de recherche pédagogique, 1997. p. 275. (Bibliothèque de l'Histoire de l'Education, 16

244 - Conversations sur plusieurs sujets de morale propres à former les jeunes demoiselles à la piété ; ouvrage utile à toutes les personnes qui sont chargées de leur éducation

Huguet Françoise. 244 - Conversations sur plusieurs sujets de morale propres à former les jeunes demoiselles à la piété ; ouvrage utile à toutes les personnes qui sont chargées de leur éducation. In: , . Les Livres pour l'Enfance et la Jeunesse de Gutenberg à Guizot. Les collections de la Bibliothèque de l'Institut National de Recherche Pédagogique. Paris : Institut national de recherche pédagogique, 1997. p. 105. (Bibliothèque de l'Histoire de l'Education, 16

425 - Rhétorique françoise à l'usage des jeunes demoiselles, avec des exemples tirés, pour la plupart, de nos meilleurs orateurs et poètes modernes. — Quatrième édition corrigée et augmentée. Avec approbation

Huguet Françoise. 425 - Rhétorique françoise à l'usage des jeunes demoiselles, avec des exemples tirés, pour la plupart, de nos meilleurs orateurs et poètes modernes. — Quatrième édition corrigée et augmentée. Avec approbation. In: , . Les Livres pour l'Enfance et la Jeunesse de Gutenberg à Guizot. Les collections de la Bibliothèque de l'Institut National de Recherche Pédagogique. Paris : Institut national de recherche pédagogique, 1997. p. 165. (Bibliothèque de l'Histoire de l'Education, 16

606 - Elémens d'histoire naturelle

Huguet Françoise. 606 - Elémens d'histoire naturelle. In: , . Les Livres pour l'Enfance et la Jeunesse de Gutenberg à Guizot. Les collections de la Bibliothèque de l'Institut National de Recherche Pédagogique. Paris : Institut national de recherche pédagogique, 1997. pp. 225-226. (Bibliothèque de l'Histoire de l'Education, 16